Gene:  PPM1D, Human

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The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53 this phosphatase negatively regulates the activity of p38 MAP kinase MAPK/p38 through which it reduces the phosphorylation of p53 and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors which suggests a role of this gene in cancer development. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: PPM1D, Human
protein phosphatase, Mg2+/Mn2+ dependent, 1D

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0016220
Info:   Same primer pair as used in probe assay qHsaCIP0030446
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PrimePCR™ Probe Assay: PPM1D, Human
protein phosphatase, Mg2+/Mn2+ dependent, 1D

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0030446
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