Gene:  NOG, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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The secreted polypeptide encoded by this gene binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes such as neural tube fusion and joint formation. Recently several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus rat and mouse. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: NOG, Human
noggin

Assay Type: SYBR® Green
Assay Design: Exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0019292
Info:   Recommended - best efficiency
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PrimePCR™ SYBR® Green Assay: NOG, Human
noggin

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0047619
Info:   Same primer pair as used in probe assay qHsaCEP0054879
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PrimePCR™ Probe Assay: NOG, Human
noggin

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0054879
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Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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