Gene:  MAP2K2, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome) a disease characterized by heart defects mental retardation and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene which is located on chromosome 7 has been identified for this gene. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: MAP2K2, Cow
Bos taurus mitogen-activated protein kinase kinase 2 (MAP2K2), mRNA.

Assay Type: SYBR® Green
Assay Design: Exonic
Application: Gene Expression
Unique Assay ID: qBtaCED0010648
List Price:    $102.00
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PrimePCR™ Probe Assay: MAP2K2, Cow
Bos taurus mitogen-activated protein kinase kinase 2 (MAP2K2), mRNA.

Assay Type: Probe
Assay Design: Exonic
Application: Gene Expression
Unique Assay ID: qBtaCEP0030410
List Price:    $196.00
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    Related pathways not available
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6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
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LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download