Gene:  LRP2, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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The protein encoded by this gene low density lipoprotein-related protein 2 (LRP2) or megalin is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain a single transmembrane domain and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin apolipoproteins B and E and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands including lipoproteins sterols vitamin-binding proteins and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq Aug 2009]

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PrimePCR™ SYBR® Green Assay: LRP2, Human
low density lipoprotein receptor-related protein 2

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0012030
Info:   Same primer pair as used in probe assay qHsaCIP0028274
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PrimePCR™ Probe Assay: LRP2, Human
low density lipoprotein receptor-related protein 2

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0028274
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PrimePCR™ ddPCR™ Mutation Assay:LRP2 p.V3050A, Human
low density lipoprotein receptor-related protein 2

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2501164
Info:   65nt amplicon; exonic; in-silico
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay:LRP2 WT for p.V3050A, Human
low density lipoprotein receptor-related protein 2

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2501165
Info:   65nt amplicon; exonic; in-silico
 
Fluorophore:   HEX
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PrimePCR™ ddPCR™ Mutation Assay:LRP2 p.S2395S, Human
low density lipoprotein receptor-related protein 2

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2502040
Info:   75nt amplicon; exonic; in-silico
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay:LRP2 WT for p.S2395S, Human
low density lipoprotein receptor-related protein 2

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2502041
Info:   75nt amplicon; exonic; in-silico
 
Fluorophore:   HEX
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PrimePCR™ ddPCR™ Mutation Assay:LRP2 p.R3399*, Human
low density lipoprotein receptor-related protein 2

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2505032
Info:   65nt amplicon; crosses exon-intron junction; in-silico
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay:LRP2 WT for p.R3399*, Human
low density lipoprotein receptor-related protein 2

Assay Type: Probe
Application: Mutation Detection in silico design
Unique Assay ID: dHsaIS2505033
Info:   65nt amplicon; crosses exon-intron junction; in-silico
 
Fluorophore:   HEX
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    Related pathways not available
Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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