Gene:  LDLR, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase the rate-limiting step in cholesterol synthesis. At the same time a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq Sep 2010]

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PrimePCR™ SYBR® Green Assay: LDLR, Human
low density lipoprotein receptor

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0015114
Info:   Same primer pair as used in probe assay qHsaCIP0029713
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PrimePCR™ Probe Assay: LDLR, Human
low density lipoprotein receptor

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0029713
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PrimePCR™ ddPCR™ Copy Number Assay: LDLR, Human
low density lipoprotein receptor

Assay Type: Probe
Application: Copy Number Variation
Unique Assay ID: dHsaCP1000455
Info:   70nt amplicon; intronic
 
Fluorophore:   FAM
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Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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