Gene:  LAMB1, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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Laminins a family of extracellular matrix glycoproteins are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion differentiation migration signaling neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha beta and gamma (formerly A B1 and B2 respectively) and they form a cruciform structure consisting of 3 short arms each formed by a different chain and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown but some of the chains have been shown to differ with respect to their tissue distribution presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha domains III and V contain several EGF-like repeats and domains IV and VI have a globular conformation. Laminin beta 1 is expressed in most tissues that produce basement membranes and is one of the 3 chains constituting laminin 1 the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment chemotaxis and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis. [provided by RefSeq Aug 2011]

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PrimePCR™ SYBR® Green Assay: LAMB1, Human
laminin, beta 1

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0006489
Info:   Same primer pair as used in probe assay qHsaCIP0026187
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PrimePCR™ Probe Assay: LAMB1, Human
laminin, beta 1

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0026187
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PrimePCR™ ddPCR™ Copy Number Assay: LAMB1, Human
laminin, beta 1

Assay Type: Probe
Application: Copy Number Variation
Unique Assay ID: dHsaCP1000401
 
Fluorophore:   FAM
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Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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