Gene:  KIR3DL2, Human

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Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes although several "framework" genes are found in all haplotypes (KIR3DL3 KIR3DP1 KIR3DL4 KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM) while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq Jun 2011]

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PrimePCR™ SYBR® Green Assay: KIR3DL2, Human
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0038985
Info:   Same primer pair as used in probe assay qHsaCEP0041707
List Price:    $125.00
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PrimePCR™ Probe Assay: KIR3DL2, Human
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0041707
List Price:    $180.00
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PrimePCR™ ddPCR™ Expression EvaGreen® Assay: KIR3DL2, Human
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2

Assay Type: EvaGreen
Application: Gene Expression
Unique Assay ID: dHsaEG5006805
Info:   EG; Same primer pair as used in qPCR assay qHsaCED0038985; exonic
List Price:    $125.00
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PrimePCR™ ddPCR™ Expression Probe Assay: KIR3DL2, Human
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5031922
Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0041707; exonic
 
Fluorophore:   FAM
List Price:    $190.00
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PrimePCR™ ddPCR™ Expression Probe Assay: KIR3DL2, Human
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5031923
Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0041707; exonic
 
Fluorophore:   HEX
List Price:    $190.00
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    Related pathways not available
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