Gene:  JAK1, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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Janus kinase 1 (JAK1) is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway and between JAK1 and JAK2 in the interferon-gamma pathway may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription or STATs. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: JAK1, Human
Janus kinase 1

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0008780
Info:   Same primer pair as used in probe assay qHsaCIP0026945
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PrimePCR™ Probe Assay: JAK1, Human
Janus kinase 1

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0026945
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Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
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LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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