Gene:  IKZF1, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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This gene encodes a transcription factor that belongs to the family of zinc-finger DNA binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. All isoforms share a common C-terminal domain which contains two zinc finger motifs that are required for hetero- or homodimerization and for interactions with other proteins. The isoforms however differ in the number of N-terminal zinc finger motifs that bind DNA and contain the nuclear localization signal resulting in members with and without DNA-binding properties. Only few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm and thought to function as dominant negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies such as acute lymphoblastic leukemia (ALL). [provided by RefSeq May 2011]

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PrimePCR™ SYBR® Green Assay: IKZF1, Human
IKAROS family zinc finger 1 (Ikaros)

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0047771
Info:   Same primer pair as used in probe assay qHsaCEP0055031
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PrimePCR™ SYBR® Green Assay: IKZF1, Human
IKAROS family zinc finger 1 (Ikaros)

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0010923
Info:   Recommended - best coverage
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PrimePCR™ Probe Assay: IKZF1, Human
IKAROS family zinc finger 1 (Ikaros)

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0055031
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PrimePCR™ ddPCR™ Copy Number Assay: IKZF1, Human
IKAROS family zinc finger 1 (Ikaros)

Assay Type: Probe
Application: Copy Number Variation
Unique Assay ID: dHsaCP1000590
 
Fluorophore:   FAM
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    Related pathways not available
Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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