Gene:  HTR2C, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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Serotonin (5-hydroxytryptamine 5-HT) a neurotransmitter elicits a wide array of physiological effects by binding to several receptor subtypes including the 5-HT2 family of seven-transmembrane-spanning G-protein-coupled receptors which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq Feb 2012]

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PrimePCR™ SYBR® Green Assay: HTR2C, Human
5-hydroxytryptamine (serotonin) receptor 2C

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0006177
Info:   Same primer pair as used in probe assay qHsaCIP0026057
List Price:    $125.00
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PrimePCR™ Probe Assay: HTR2C, Human
5-hydroxytryptamine (serotonin) receptor 2C

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0026057
List Price:    $180.00
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PrimePCR™ ddPCR™ Expression EvaGreen® Assay: HTR2C, Human
5-hydroxytryptamine (serotonin) receptor 2C

Assay Type: EvaGreen
Application: Gene Expression
Unique Assay ID: dHsaEG5014259
Info:   EG; Same primer pair as used in qPCR assay qHsaCID0006177; Intron-spanning
List Price:    $125.00
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PrimePCR™ ddPCR™ Expression Probe Assay: HTR2C, Human
5-hydroxytryptamine (serotonin) receptor 2C

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5046576
Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0026057; Intron-spanning
 
Fluorophore:   FAM
List Price:    $190.00
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PrimePCR™ ddPCR™ Expression Probe Assay: HTR2C, Human
5-hydroxytryptamine (serotonin) receptor 2C

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5046577
Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0026057; Intron-spanning
 
Fluorophore:   HEX
List Price:    $190.00
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Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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