Gene:  ERCC1, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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The product of this gene functions in the nucleotide excision repair pathway and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4) and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule epsilon associated protein gene on the opposite strand. [provided by RefSeq Oct 2009]

PrimePCR™ SYBR® Green Assay: ERCC1, Human
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0008822
Info:   Same primer pair as used in probe assay qHsaCIP0026963
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PrimePCR™ Probe Assay: ERCC1, Human
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0026963
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    Related pathways not available
Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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