Gene:  COX11, Human

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Cytochrome c oxidase (COX) the terminal component of the mitochondrial respiratory chain catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit but may be a heme A biosynthetic enzyme involved in COX formation according to the yeast mutant studies. However the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene has been found on chromosome 6. [provided by RefSeq Jun 2009]

PrimePCR™ SYBR® Green Assay: COX11, Human
COX11 cytochrome c oxidase assembly homolog (yeast)

Assay Type: SYBR® Green
Assay Design: Exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0004875
Info:   Same primer pair as used in probe assay qHsaCEP0025887
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PrimePCR™ Probe Assay: COX11, Human
COX11 cytochrome c oxidase assembly homolog (yeast)

Assay Type: Probe
Assay Design: Exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0025887
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    Related pathways not available
Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
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LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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