Gene:  COL18A1, Human

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This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Sep 2008]

PrimePCR™ SYBR® Green Assay: COL18A1, Human
collagen, type XVIII, alpha 1

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0012310
Info:   Same primer pair as used in probe assay qHsaCIP0028389
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PrimePCR™ Probe Assay: COL18A1, Human
collagen, type XVIII, alpha 1

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0028389
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    Related pathways not available
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