Gene:  CHRNA7, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains a variable cytoplasmic loop a fourth conserved transmembrane domain and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by and highly sensitive to alpha-bungarotoxin. Once this receptor binds acetylcholine it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq Feb 2012]

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PrimePCR™ SYBR® Green Assay: CHRNA7, Human
cholinergic receptor, nicotinic, alpha 7

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0038862
Info:   Same primer pair as used in probe assay qHsaCEP0041584
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PrimePCR™ Probe Assay: CHRNA7, Human
cholinergic receptor, nicotinic, alpha 7

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0041584
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PrimePCR™ ddPCR™ Copy Number Assay: CHRNA7, Human
cholinergic receptor, nicotinic, alpha 7

Assay Type: Probe
Application: Copy Number Variation
Unique Assay ID: dHsaCP1000530
 
Fluorophore:   FAM
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Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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