Gene:  CDKN1A, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53 through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA) a DNA polymerase accessory factor and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases which thus leads to a dramatic activation of CDK2 and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq Nov 2010]

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PrimePCR™ SYBR® Green Assay: CDKN1A, Human
cyclin-dependent kinase inhibitor 1A (p21, Cip1)

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0014498
Info:   Same primer pair as used in probe assay qHsaCIP0029411
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PrimePCR™ Probe Assay: CDKN1A, Human
cyclin-dependent kinase inhibitor 1A (p21, Cip1)

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0029411
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PrimePCR™ ddPCR™ Copy Number Assay: CDKN1A, Human
cyclin-dependent kinase inhibitor 1A (p21, Cip1)

Assay Type: Probe
Application: Copy Number Variation
Unique Assay ID: dHsaCP2500375
Info:   62nt amplicon; exonic
 
Fluorophore:   FAM
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Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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