Gene:  CDK5R1, Human

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The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau which contributes to Alzheimer's disease. [provided by RefSeq Jul 2008]

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PrimePCR™ SYBR® Green Assay: CDK5R1, Human
cyclin-dependent kinase 5, regulatory subunit 1 (p35)

Assay Type: SYBR® Green
Assay Design: Exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0002392
List Price:    $125.00
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PrimePCR™ SYBR® Green Assay: CDK5R1, Human
cyclin-dependent kinase 5, regulatory subunit 1 (p35)

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0047204
Info:   Recommended - best coverage; Same primer pair as used in probe assay qHsaCEP0054465
List Price:    $125.00
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Add to Custom Plate
PrimePCR™ Probe Assay: CDK5R1, Human
cyclin-dependent kinase 5, regulatory subunit 1 (p35)

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0054465
List Price:    $180.00
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PrimePCR™ ddPCR™ Expression EvaGreen® Assay: CDK5R1, Human
cyclin-dependent kinase 5, regulatory subunit 1 (p35)

Assay Type: EvaGreen
Application: Gene Expression
Unique Assay ID: dHsaEG5001109
Info:   EG; Same primer pair as used in qPCR assay qHsaCED0002392; Exonic
List Price:    $125.00
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PrimePCR™ ddPCR™ Expression EvaGreen® Assay: CDK5R1, Human
cyclin-dependent kinase 5, regulatory subunit 1 (p35)

Assay Type: EvaGreen
Application: Gene Expression
Unique Assay ID: dHsaEG5011561
Info:   EG; Same primer pair as used in qPCR assay qHsaCED0047204; exonic
List Price:    $125.00
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PrimePCR™ ddPCR™ Expression Probe Assay: CDK5R1, Human
cyclin-dependent kinase 5, regulatory subunit 1 (p35)

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5041432
Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0054465; exonic
 
Fluorophore:   FAM
List Price:    $190.00
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PrimePCR™ ddPCR™ Expression Probe Assay: CDK5R1, Human
cyclin-dependent kinase 5, regulatory subunit 1 (p35)

Assay Type: Probe
Application: Gene Expression
Unique Assay ID: dHsaCPE5041433
Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0054465; exonic
 
Fluorophore:   HEX
List Price:    $190.00
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Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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