Gene:  CCNE1, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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The protein encoded by this gene belongs to the highly conserved cyclin family whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2 whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors which results in chromosome instability and thus may contribute to tumorigenesis. This protein was found to associate with and be involved in the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus) which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene which encode distinct isoforms have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. [provided by RefSeq Jul 2008]

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PrimePCR™ SYBR® Green Assay: CCNE1, Human
cyclin E1

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0015131
Info:   Same primer pair as used in probe assay qHsaCIP0029726
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PrimePCR™ Probe Assay: CCNE1, Human
cyclin E1

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0029726
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PrimePCR™ ddPCR™ Copy Number Assay: CCNE1, Human
cyclin E1

Assay Type: Probe
Application: Copy Number Variation
Unique Assay ID: dHsaCP1000012
 
Fluorophore:   FAM
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Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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