Gene:  BRCA1, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors DNA damage sensors and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II and through the C-terminal domain also interacts with histone deacetylase complexes. This protein thus plays a role in transcription DNA repair of double-stranded breaks and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants some of which are disease-associated mutations have been described for this gene but the full-length natures of only some of these variants has been described. A related pseudogene which is also located on chromosome 17 has been identified. [provided by RefSeq May 2009]

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PrimePCR™ SYBR® Green Assay: BRCA1, Human
breast cancer 1, early onset

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0038604
Info:   Same primer pair as used in probe assay qHsaCEP0041326
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PrimePCR™ Probe Assay: BRCA1, Human
breast cancer 1, early onset

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0041326
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PrimePCR™ ddPCR™ Copy Number Assay: BRCA1, Human
breast cancer 1, early onset

Assay Type: Probe
Application: Copy Number Variation
Unique Assay ID: dHsaCP1000008
Info:   82nt amplicon; intronic
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Copy Number Assay: BRCA1, Human
breast cancer 1, early onset

Assay Type: Probe
Application: Copy Number Variation
Unique Assay ID: dHsaCP2500367
Info:   63nt amplicon; crosses exon-intron junction
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay:BRCA1 p.S114S, Human
breast cancer 1, early onset

Assay Type: Probe
Application: In Silico Mutation Detection
Unique Assay ID: dHsaIS2504826
Info:   99nt amplicon; crosses exon-intron junction; in-silico designed
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay:BRCA1 WT for p.S114S, Human
breast cancer 1, early onset

Assay Type: Probe
Application: In Silico Mutation Detection
Unique Assay ID: dHsaIS2504827
Info:   99nt amplicon; crosses exon-intron junction; in-silico designed
 
Fluorophore:   HEX
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PrimePCR™ ddPCR™ Mutation Assay:BRCA1 p.S1009P, Human
breast cancer 1, early onset

Assay Type: Probe
Application: In Silico Mutation Detection
Unique Assay ID: dHsaIS2505592
Info:   69nt amplicon; exonic; in-silico designed
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay:BRCA1 WT for p.S1009P, Human
breast cancer 1, early onset

Assay Type: Probe
Application: In Silico Mutation Detection
Unique Assay ID: dHsaIS2505593
Info:   69nt amplicon; exonic; in-silico designed
 
Fluorophore:   HEX
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Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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