Gene:  ATRX, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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The protein encoded by this gene contains an ATPase/helicase domain and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation which may provide a link between chromatin remodeling DNA methylation and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation which regulates its nuclear matrix and chromatin association and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq Jul 2008]

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PrimePCR™ SYBR® Green Assay: ATRX, Human
alpha thalassemia/mental retardation syndrome X-linked

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0042522
Info:   Same primer pair as used in probe assay qHsaCEP0049784
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PrimePCR™ SYBR® Green Assay: ATRX, Human
alpha thalassemia/mental retardation syndrome X-linked

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0010314
Info:   Recommended - best coverage
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PrimePCR™ Probe Assay: ATRX, Human
alpha thalassemia/mental retardation syndrome X-linked

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0049784
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PrimePCR™ ddPCR™ Copy Number Assay: ATRX, Human
alpha thalassemia/mental retardation syndrome X-linked

Assay Type: Probe
Application: Copy Number Variation
Unique Assay ID: dHsaCP1000559
 
Fluorophore:   FAM
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    Related pathways not available
Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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