Gene:  ALPL, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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There are at least four distinct but related alkaline phosphatases: intestinal placental placental-like and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is therefore referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary however depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described. [provided by RefSeq Apr 2010]

PrimePCR™ SYBR® Green Assay: ALPL, Human
alkaline phosphatase, liver/bone/kidney

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0045991
Info:   Recommended - best coverage; Same primer pair as used in probe assay qHsaCEP0053252
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PrimePCR™ SYBR® Green Assay: ALPL, Human
alkaline phosphatase, liver/bone/kidney

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0010031
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PrimePCR™ Probe Assay: ALPL, Human
alkaline phosphatase, liver/bone/kidney

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0053252
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Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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