Gene:  AKT1, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1 which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq Jul 2011]

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PrimePCR™ SYBR® Green Assay: AKT1, Human
v-akt murine thymoma viral oncogene homolog 1

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0011338
Info:   Same primer pair as used in probe assay qHsaCIP0027973
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PrimePCR™ Probe Assay: AKT1, Human
v-akt murine thymoma viral oncogene homolog 1

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0027973
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PrimePCR™ ddPCR™ Copy Number Assay: AKT1, Human
v-akt murine thymoma viral oncogene homolog 1

Assay Type: Probe
Application: Copy Number Variation
Unique Assay ID: dHsaCP1000364
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay: AKT1 p.E17K, Human
v-akt murine thymoma viral oncogene homolog 1

Assay Type: Probe
Application: Mutation Detection
Unique Assay ID: dHsaCP2000031
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay: AKT1 WT for p.E17K, Human
v-akt murine thymoma viral oncogene homolog 1

Assay Type: Probe
Application: Mutation Detection
Unique Assay ID: dHsaCP2000032
 
Fluorophore:   HEX
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Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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