Gene:  AIFM1, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. [provided by RefSeq May 2010]

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PrimePCR™ SYBR® Green Assay: AIFM1, Human
apoptosis-inducing factor, mitochondrion-associated, 1

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0022006
Info:   Same primer pair as used in probe assay qHsaCIP0033258
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PrimePCR™ Probe Assay: AIFM1, Human
apoptosis-inducing factor, mitochondrion-associated, 1

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0033258
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PrimePCR™ ddPCR™ Mutation Assay:AIFM1 p.D87D, Human
apoptosis-inducing factor, mitochondrion-associated, 1

Assay Type: Probe
Application: In Silico Mutation Detection
Unique Assay ID: dHsaIS2505942
Info:   77nt amplicon; crosses exon-intron junction; in-silico designed
 
Fluorophore:   FAM
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PrimePCR™ ddPCR™ Mutation Assay:AIFM1 WT for p.D87D, Human
apoptosis-inducing factor, mitochondrion-associated, 1

Assay Type: Probe
Application: In Silico Mutation Detection
Unique Assay ID: dHsaIS2505943
Info:   77nt amplicon; crosses exon-intron junction; in-silico designed
 
Fluorophore:   HEX
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Number Description Download
6262 PrimePCR Assays: Meeting the MIQE Guidelines by Full Wet-Lab Validation, Rev B Click to download
6263 PrimePCR Pathway Analysis: Pathway Curation and Real-Time PCR Panel Design Strategy, Rev B Click to download
6290 PrimePCR Assays and Panels Brochure, Rev D Click to download
LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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