Gene:  ABAT, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA) an important mostly inhibitory neurotransmitter in the central nervous system into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation hypotonia hyperreflexia lethargy refractory seizures and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: ABAT, Human
4-aminobutyrate aminotransferase

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0016560
Info:   Same primer pair as used in probe assay qHsaCIP0030666
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PrimePCR™ Probe Assay: ABAT, Human
4-aminobutyrate aminotransferase

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0030666
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Number Description Download
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LIT10026370 Instruction Manual, PrimePCR Assays, Panels, and Controls, Rev E Click to download
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