Foresight Pro Chromatography Columns, CHT Ceramic Hydroxyapatite

Foresight Pro Chromatography Columns, CHT Ceramic Hydroxyapatite

Foresight Pro CHT prepacked columns are GMP ready and specifically designed to be used for all biopharmaceutical purification workflows. This includes a wide variety of purification and polishing applications for vaccines, monoclonal antibodies, and recombinant proteins.

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Overview

foresight pro chromatography 1

5–33 cm ID Columns


foresight pro chromatography 2

45 cm ID Columns

Foresight Pro Chromatography Columns are good manufacturing practice (GMP) ready columns specifically designed to be used for all biopharmaceutical manufacturing applications. The columns have a sanitary design with minimal dead space and effective cleanability, and connections to pumping systems are made via standard 3/4" Tri-Clamp Fittings. CHT prepacked columns are available in a range of column diameters and bed heights. CHT prepacked columns are shipped in 0.1 N NaOH.

Features and Benefits

  • GMP ready columns — validated and ready to use
  • Excellent performance — data include asymmetry, HETP, endotoxin, and bioburden
  • Patented and robust column hardware design maintains CHT packed bed
  • Columns maintain performance criteria after shipping and cycling
  • Columns maintain performance criteria post shipping and post cycling
  • All wetted parts meet USP Class VI requirements of USP <88>
  • Standard Tri-Clamp connections — plug and play
  • Columns are packed in a controlled ISO Class 7 cleanroom
  • Range of column diameters and bed heights — 5–45 cm ID and 10 or 20 cm bed height
  • Resin reference sample included with each column
  • Regulatory support file available

Packing Quality

The performance of the Foresight Pro Columns was evaluated before and after International Safe Transit Association (ISTA). As shown in Figures 1 and 2 the columns maintained performance criteria indicating excellent stability during shipping. For more details see Bulletin 3291.

  • Packing Quality Figure 3

    Figure 1: Evaluation of N/m, comparing pre- and post-ISTA tests. Pre-ISTA test (); Post-ISTA test(); ISTA, International Safe Transit Association; N/m, number of theoretical plates per meter.

  • Packing Quality Figure 4

    Figure 2: Evaluation of As, comparing pre- and post-ISTA tests. Pre-ISTA test (); Post-ISTA test(); As, asymmetry factor; ID, inner diameter; ISTA, International Safe Transit Association.

Cycling Data

The performance of the Foresight Pro Columns was evaluated for flow stability. The columns went through a series of cycles. Figures 3 and 4 show that the columns maintained performance criteria indicating a robust packed CHT bed. For more details see Bulletin 3291.

  • Cycling Figure 5

    Figure 3: Evaluation of N/m, comparing the first and tenth cycle of Foresight Pro Columns.
    First cycle (); Tenth cycle ()

  • Cycling Figure 6

    Figure 4: Evaluation of As, comparing the first and tenth cycle of Foresight Pro Columns.
    Pre-ISTA 2A (); Post-ISTA 2A()

Non-Product Contact Material Summary

Element Material
Top and bottom supporting plates Polypropylene
Holding bars Polyamide or 304 stainless steel
Wheels Rubber wheel with stainless steel support plate and 2 locking casters

Product Contact Material Summary

Element Material USP <88> Class CFR 21 177 Animal Origin
Column body Glass (5 cm ID columns) N/A N/A N/A
Column body

Acrylic (8, 10, 13, 20, 24, 33, 45 cm ID columns)

Class VI 177.1010 Animal-free
Flow distributors Polypropylene Class VI 177.1520 Animal-free
Inlet and outlet connectors Polypropylene Class VI 177.1520 Animal-free
Tubing connections Reinforced elastomer tubing Class VI 177.2600 Animal-free
Tri-Clamp Gasket and O-rings Ethylene propylene diene monomer (EPDM) Class VI 177.2600 Animal-free
Bed support screens Polyamide

Note: The polyamide bed support screen is welded
to the polypropylene flow distributor without using any extra chemicals

Class VI 177.1500 Animal-free

Related Products

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Specifications

Column efficiency, plates/meter
≥ 4,800
Column asymmetry
0.80 ≤ As ≤ 2.2
Microbial bioburden, CFU/ml
< 10
Endotoxin level, EU/ml
< 0.25
Column shipping solution
0.1 N NaOH

Ordering

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Foresight Chromatography Column 12014659
12014659

Foresight Pro Chromatography Column, 0.2 L CHT Ceramic Hydroxyapatite, Type I, 40 µm, 5 cm (diameter) x 10 cm (length)

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Foresight Chromatography Column 12014660
12014660

Foresight Pro Chromatography Column, 0.4 L CHT Ceramic Hydroxyapatite, Type I, 40 µm, 5 cm (diameter) x 20 cm (length)

Image
Foresight Chromatography Column 12014671
12014671

Foresight Pro Chromatography Column, 0.5 L CHT Ceramic Hydroxyapatite, Type I, 40 µm, 8 cm (diameter) x 10 cm (length)

Image
Foresight Chromatography Column 12014672
12014672

Foresight Pro Chromatography Column, 1.0 L CHT Ceramic Hydroxyapatite, Type I, 40 µm, 8 cm (diameter) x 20 cm (length)

Image
Foresight Chromatography Column 12014673
12014673

Foresight Pro Chromatography Column, 0.8 L CHT Ceramic Hydroxyapatite, Type I, 40 µm, 10 cm (diameter) x 10 cm (length)

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12014674 Foresight Pro Column Thumbnail
12014674

Foresight Pro Chromatography Column, 1.5 L CHT Ceramic Hydroxyapatite, Type I, 40 µm, 10 cm (diameter) x 20 cm (length)

Image
Foresight Chromatography Column 12014675
12014675

Foresight Pro Chromatography Column, 1.3 L CHT Ceramic Hydroxyapatite, Type I, 40 µm, 13 cm (diameter) x 10 cm (length)

Image
Foresight Chromatography Columns 12014676 Thumbnail
12014676

Foresight Pro Chromatography Column, 2.7 L CHT Ceramic Hydroxyapatite, Type I, 40 µm, 13 cm (diameter) x 20 cm (length)

Image
Foresight Chromatography Column 12014677
12014677

Foresight Pro Chromatography Column, 3.1 L CHT Ceramic Hydroxyapatite, Type I, 40 µm, 20 cm (diameter) x 10 cm (length)

Image
Foresight Chromatography Column 12014678 Thumbnail
12014678

Foresight Pro Chromatography Column, 6.3 L CHT Ceramic Hydroxyapatite, Type I, 40 µm, 20 cm (diameter) x 20 cm (length)

Image
Foresight Chromatography Column 12014679
12014679

Foresight Pro Chromatography Column, 4.5 L CHT Ceramic Hydroxyapatite, Type I, 40 µm, 24 cm (diameter) x 10 cm (length)

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Foresight Chromatography Column 12014680
12014680

Foresight Pro Chromatography Column, 9.0 L CHT Ceramic Hydroxyapatite, Type I, 40 µm, 24 cm (diameter) x 20 cm (length)

Image
Foresight Chromatography Column 12014681
12014681

Foresight Pro Chromatography Column, 8.5 L CHT Ceramic Hydroxyapatite, Type I, 40 µm, 33 cm (diameter) x 10 cm (length)

Image
Foresight Pro Chromatography Column 12014682 Thumbnail
12014682

Foresight Pro Chromatography Column, 17 L, CHT Ceramic Hydroxyapatite, Type I, 40 µm, 33 cm (diameter) x 20 cm (length)

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Foresight Chromatography Column 12014697
12014697

Foresight Pro Chromatography Column, 0.2 L CHT Ceramic Hydroxyapatite, Type II, 40 µm, 5 cm (diameter) x 10 cm (length)

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Foresight Chromatograph Column 12014698 Thumbnail
12014698

Foresight Pro Chromatography Column, 0.4 L CHT Ceramic Hydroxyapatite, Type II, 40 µm, 5 cm (diameter) x 20 cm (length)

Image
Foresight Chromatography Column 12014699
12014699

Foresight Pro Chromatography Column, 0.5 L CHT Ceramic Hydroxyapatite, Type II, 40 µm, 8 cm (diameter) x 10 cm (length)

Image
Foresight Chromatography Column 12014700
12014700

Foresight Pro Chromatography Column, 1.0 L CHT Ceramic Hydroxyapatite, Type II, 40 µm, 8 cm (diameter) x 20 cm (length)

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Foresight Chromatography Column 12014701
12014701

Foresight Pro Chromatography Column, 0.8 L CHT Ceramic Hydroxyapatite, Type II, 40 µm, 10 cm (diameter) x 10 cm (length)

Image
Foresight Chromatography Column 12014702
12014702

Foresight Pro Chromatography Column, 1.5 L CHT Ceramic Hydroxyapatite, Type II, 40 µm, 10 cm (diameter) x 20 cm (length)

Image
Foresight Chromatography Column 12014703
12014703

Foresight Pro Chromatography Column, 1.3 L CHT Ceramic Hydroxyapatite, Type II, 40 µm, 13 cm (diameter) x 10 cm (length)

Image
Foresight Chromatography Column 12014704 Thumbnail
12014704

Foresight Pro Column, 2.7 L CHT Ceramic Hydroxyapatite, Type II, 40 µm, 13 cm (diameter) x 20 cm (length)

Image
Foresight Chromatography Column 12014705
12014705

Foresight Pro Chromatography Column, 3.1 L CHT Ceramic Hydroxyapatite, Type II, 40 µm, 20 cm (diameter) x 10 cm (length)

Image
Foresight Chromatography Column 12014706 Thumbnail
12014706

Foresight Pro Chromatography Column, 6.3 L CHT Ceramic Hydroxyapatite, Type II, 40 µm, 20 cm (diameter) x 20 cm (length)

Image
Foresight Chromatography Column 12014707
12014707

Foresight Pro Chromatography Column, 4.5 L CHT Ceramic Hydroxyapatite, Type II, 40 µm, 24 cm (diameter) x 10 cm (length)

Image
Foresight Chromatography Column 12014708
12014708

Foresight Pro Chromatography Column, 9.0 L CHT Ceramic Hydroxyapatite, Type II, 40 µm, 24 cm (diameter) x 20 cm (length)

Image
Foresight Chromatography Column 12014709
12014709

Foresight Pro Chromatography Column, 8.5 L CHT Ceramic Hydroxyapatite, Type II, 40 µm, 33 cm (diameter) x 10 cm (length)

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Foresight Chromatograph Column 12014710 Thumbnail
12014710

Foresight Pro Chromatography Column, 17 L CHT Ceramic Hydroxyapatite, Type II, 40 µm, 33 cm (diameter) x 20 cm (length)

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Foresight Chromatography Column 12014725
12014725

Foresight Pro Chromatography Column, 0.2 L CHT Ceramic Hydroxyapatite XT, 40 µm, 5 cm (diameter) x 10 cm (length)

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Foresight Chromatography Column 12014726 Thumbnail
12014726

Foresight Pro Chromatography Column, 0.4 L CHT Ceramic Hydroxyapatite XT 40 µm, 5 cm (diameter) x 20 cm (length)

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Foresight Chromatography Column 12014727
12014727

Foresight Pro Chromatography Column, 0.5 L CHT Ceramic Hydroxyapatite XT 40 µm, 8 cm (diameter) x 10 cm (length)

Image
Foresight Chromatography Column 12014728
12014728

Foresight Pro Chromatography Column, 1.0 L CHT Ceramic Hydroxyapatite XT, 40 µm, 8 cm (diameter) x 20 cm (length)

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Foresight Chromatography Column 12014729
12014729

Foresight Pro Chromatography Column, 0.8 L CHT Ceramic Hydroxyapatite XT 40 µm, 10 cm (diameter) x 10 cm (length)

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Foresight Chromatography Column 12014730
12014730

Foresight Pro Chromatography Column, 1.5 L CHT Ceramic Hydroxyapatite XT, 40 µm, 10 cm (diameter) x 20 cm (length)

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Foresight Chromatography Column 12014675
12014731

Foresight Pro Chromatography Column, 1.3 L CHT Ceramic Hydroxyapatite XT, 40 µm, 13 cm (diameter) x 10 cm (length)

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Foresight Chromatography Column 12014732 Thumbnail
12014732

Foresight Pro Chromatography Column, 2.7 L CHT Ceramic Hydroxyapatite XT, 40 µm, 13 cm (diameter) x 20 cm (length)

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Foresight Chromatography Column 12014733
12014733

Foresight Pro Chromatography Column, 3.1 L CHT Ceramic Hydroxyapatite XT, 40 µm, 20 cm (diameter) x 10 cm (length)

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Foresight Chromatography Column 12014734 Thumbnail
12014734

Foresight Pro Chromatography Column, 6.3 L CHT Ceramic Hydroxyapatite XT, 40 µm, 20 cm (diameter) x 20 cm (length)

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Foresight Chromatography Column 12014735
12014735

Foresight Pro Chromatography Column, 4.5 L CHT Ceramic Hydroxyapatite XT, 40 µm, 24 cm (diameter) x 10 cm (length)

Image
Foresight Chromatography Column 12014736
12014736

Foresight Pro Chromatography Column, 9.0 L CHT Ceramic Hydroxyapatite XT, 40 µm, 24 cm (diameter) x 20 cm (length)

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Foresight Chromatography Column 12014737
12014737

Foresight Pro Chromatography Column, 8.5 L CHT Ceramic Hydroxyapatite XT, 40 µm, 33 cm (diameter) x 10 cm (length)

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Foresight Chromatography Column 12014738 Thumbnail
12014738

Foresight Pro Chromatography Column, 17 L CHT Ceramic Hydroxyapatite XT, 40 µm, 33 cm (diameter) x 20 cm (length)

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12020395
12020395

Foresight Pro Column, 16 L CHT Ceramic Hydroxyapatite, Type I, 40 µm, 45 cm (diameter) x 10 cm (length)

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12020396
12020396

Foresight Pro Column, 32 L CHT Ceramic Hydroxyapatite, Type I, 40 µm, 45 cm (diameter) x 20 cm (length)

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12020397
12020397

Foresight Pro Column, 16 L CHT Ceramic Hydroxyapatite, Type II, 40 µm, 45 cm (diameter) x 10 cm (length)

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12020398
12020398

Foresight Pro Column, 32 L CHT Ceramic Hydroxyapatite, Type II, 40 µm, 45 cm (diameter) x 20 cm (length)

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12020399
12020399

Foresight Pro Column, 16 L CHT Ceramic Hydroxyapatite, XT, 40 µm, 45 cm (diameter) x 10 cm (length)

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12020400-sku-view
12020400

Foresight Pro Column, 32 L CHT Ceramic Hydroxyapatite, XT, 40 µm, 45 cm (diameter) x 20 cm (length)

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