Abstract:
A ProteOn XPR36 protein interaction array system was used to characterize a set of small molecule enzyme interactions. With a single injection into the ProteOn system's crisscross flow system, response data was collected for six concentrations of each analyte over six target protein surfaces. This "one-shot" approach to kinetic analysis improves throughput while generating high-quality data. Results illustrate the potential of this parallel-processing biosensor to increase the speed of kinetic analysis in drug discovery and to expand the applications of real-time protein interaction arrays.
About the speakers:
Dr. David Myszka is the founder and director of the Center for Biomolecular Interaction Analysis at the University of Utah.