Bio-Plex Pro™ RBM Canine Kidney Toxicity Assays

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Bio-Plex Pro™ RBM Canine Kidney Toxicity Assays

Overview

Available Bio-Plex Pro™ RBM Canine Kidney Toxicity Assays
Canine Kidney Toxicity Panel 1
(171-QTR1CK)
Analyte Bead Region
Clusterin 12
KIM-1 53
MCP-1 15
NGAL 46
Canine Kidney Toxicity Albumin Kit
(171-QTR2CK)
Analyte Bead Region
Albumin 30
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The Bio-Plex Pro RBM kidney toxicity assays, developed in partnership with Myriad RBM, comprise a highly relevant set of biomarkers for early detection and characterization of kidney toxicity/injury. Myriad RBM’s close collaboration with the Predictive Safety Testing Consortium (PSTC), FDA, and European Medicines Evaluation Agency (EMEA) was instrumental in the selection of markers found in these panels.

The assays are built on magnetic beads to enable robust quantification of multiple proteins in canine urine samples, providing valuable information throughout drug development — from lead optimization to preclinical and clinical protocol decision making. Assays are offered as premixed all-in-one kits for research involving:

  • Drug-induced kidney toxicity
  • Diabetes
  • High blood pressure
  • Glomerulonephritis
  • Polycystic kidney disease
  • Chronic infection
  • SLE (lupus) and other autoimmune disorders

Bio-Plex Pro RBM canine kidney toxicity assays are available as one panel and an albumin kit:

Panel 1
  • Clusterin
  • KIM-1
  • MCP-1
  • NGAL
Albumin Kit
  • Albumin

Based on 6.5 µm magnetic beads, these assay panels are compatible with both vacuum and magnetic wash stations. Magnetic washing simplifies plate processing, provides increased throughput, and results in decreased variability and increased reproducibility.

Key Features

  • Optimized for high precision and lot-to-lot reproducibility of sample measurements
  • Magnetic beads for simplified plate processing
  • 2-level quality controls with lot-specific ranges for kits
  • Assay quick guide to get you started right away
  • High-quality design ensures robust and reproducible measurement of nephrotoxicity biomarkers in human, rat, and canine urine samples

Ordering Options

Premixed, all-in-one ktis

Instrument Compatibility

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Bio-Plex Pro™ Flat Bottom Plates

171025001
Pkg of 40, 96-well plate, for use with Bio-Plex Pro wash stations when using magnetic bead–based assays

171025001 /templatedata/internet/product_SKU/data/LSR/Bio-Plex-Suspension-Array-Syst/Bio-Plex-Pro-Magnetic-Cytokine/171-025001_0921120724536.xml 171025001 /default/main/bio-rad/WORKAREA/default 09/21/09 12:07 PM en_US jal7kch3 2017-11-14 07:07:47 true true internet/product_SKU jal7kch3 templatedata/internet/product_SKU/data/LSR/Bio-Plex-Suspension-Array-Syst/Bio-Plex-Pro-Magnetic-Cytokine/171-025001_0921120724536.xml LSR 2019-05-04 17:50:12 /default/main/bio-rad/STAGING N /default/main/bio-rad en 12/31/37 11:59 PM 1555976988443 AE,AI,AL,AM,AR,AT,AU,AZ,BA,BD,BE,BF,BG,BH,BN,BO,BR,BW,CA,CH,CL,CM,CN,CO,CR,CY,CZ,DE,DK,DO,DZ,EC,EE,EG,EH,ER,ES,ET,FI,FM,FO,FR,GA,GE,GF,GH,GP,GR,GT,GU,HK,HN,HR,HT,HU,ID,IE,IL,IN,IS,IT,JM,JO,JP,KE,KH,KR,KW,KZ,LB,LI,LK,LT,LU,LV,MA,MD,MG,MK,ML,MO,MQ,MS,MT,MU,MX,MY,NG,NI,NL,NO,NP,NZ,OM,PA,PE,PF,PG,PH,PK,PL,PR,PS,PT,PW,PY,QA,RO,RS,RU,SA,SB,SE,SG,SI,SK,SN,ST,SV,TG,TH,TN,TO,TR,TT,TW,TZ,UA,UG,UK,US,UY,UZ,VA,VE,VU,XK,YE,ZA,VN 2019-05-04 17:50:12 /default/main/bio-rad/WORKAREA/default/templatedata/internet/product_SKU/data/LSR/Bio-Plex-Suspension-Array-Syst/Bio-Plex-Pro-Magnetic-Cytokine/171-025001_0921120724536.xml templatedata/internet/product_SKU/data/LSR/Bio-Plex-Suspension-Array-Syst/Bio-Plex-Pro-Magnetic-Cytokine/171-025001_0921120724536.xml 171025001-bio-plex-pro-flat-bottom-plates 171025001 Bio-Plex Pro Flat Bottom Plates Bio-Plex Pro™ Flat Bottom Plates Pkg of 40, 96-well plate, for use with Bio-Plex Pro wash stations when using magnetic bead–based assays Pkg of 40, 96-well plate, for use with Bio-Plex Pro wash stations when using magnetic bead-based assays Pkg of 40, 96-well plate, for use with Bio-Plex Pro wash stations when using magnetic bead–based assays /webroot/web/images/lsr/products/bioplex_suspension_array/sku_thumb/global/171-025001b_tn.jpg /webroot/web/images/lsr/products/bioplex_suspension_array/sku_view/global/171-025001b_view.jpg /webroot/web/images/lsr/products/bioplex_suspension_array/sku_feature/global/171-025001b_feature.jpg ,VN RepEx 171-025001 Pkg of 40, 96-well plate, for use with Bio-Plex Pro wash stations when using magnetic bead-based assays 171025001, bio-plex, pro, flat, bottom, plates, wash, stations, bioplex, multiplex, singleplex, bead-based, assay, assays, immunoassay, coupled, magnetic, beads, detection 09/21/09 12:07 PM 12/31/37 11:59 PM AE,AI,AL,AM,AR,AT,AU,AZ,BA,BD,BE,BF,BG,BH,BN,BO,BR,BW,CA,CH,CL,CM,CN,CO,CR,CY,CZ,DE,DK,DO,DZ,EC,EE,EG,EH,ER,ES,ET,FI,FM,FO,FR,GA,GE,GF,GH,GP,GR,GT,GU,HK,HN,HR,HT,HU,ID,IE,IL,IN,IS,IT,JM,JO,JP,KE,KH,KR,KW,KZ,LB,LI,LK,LT,LU,LV,MA,MD,MG,MK,ML,MO,MQ,MS,MT,MU,MX,MY,NG,NI,NL,NO,NP,NZ,OM,PA,PE,PF,PG,PH,PK,PL,PR,PS,PT,PW,PY,QA,RO,RS,RU,SA,SB,SE,SG,SI,SK,SN,ST,SV,TG,TH,TN,TO,TR,TT,TW,TZ,UA,UG,UK,US,UY,UZ,VA,VE,VU,XK,YE,ZA,VN en LSR /LSR/Bio-Plex-Suspension-Array-Syst/Bio-Plex-Pro-Magnetic-Cytokine N 0 30034376 /templatedata/internet/product_SKU/data/LSR/Bio-Plex-Suspension-Array-Syst/Bio-Plex-Instruments/300-34376_0921120736052.xml false $274.00 false $ null true false true true false USD true true true /prd/en/US/adirect/biorad?cmd=ajaxAddToCart&AddToCartProductID=171025001&quantity= false false /prd/en/US/adirect/biorad?cmd=ajaxAddToCart&AddToCartProductID=171025001&CartQuote=QT&quantity= 1490 false true false /prd/en/US/adirect/biorad?cmd=ajaxAddToCart&AddToCartProductID=171025001&AddToDefaultWishList=true&quantity= 41122100 274.00 Product detail page 171025001
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Bio-Plex Pro™ Wash Station

30034376
Microplate wash station for magnetic bead–based assays, includes magnetic plate carrier, waste bottle, 2 buffer bottles

30034376 /templatedata/internet/product_SKU/data/LSR/Bio-Plex-Suspension-Array-Syst/Bio-Plex-Instruments/300-34376_0921120736052.xml 30034376 /default/main/bio-rad/WORKAREA/default 09/21/09 12:07 PM en_US jal7kchp 2017-11-14 07:07:44 true true internet/product_SKU jal7kchp templatedata/internet/product_SKU/data/LSR/Bio-Plex-Suspension-Array-Syst/Bio-Plex-Instruments/300-34376_0921120736052.xml LSR 2019-05-04 17:50:14 /default/main/bio-rad/STAGING N /default/main/bio-rad en 12/31/37 11:59 PM 1555978864664 AE,AI,AL,AM,AR,AT,AU,AZ,BA,BD,BE,BF,BG,BH,BN,BO,BR,BW,CA,CH,CL,CM,CN,CO,CR,CY,CZ,DE,DK,DO,DZ,EC,EE,EG,EH,ER,ES,ET,FI,FM,FO,FR,GA,GE,GF,GH,GP,GR,GT,GU,HK,HN,HR,HT,HU,ID,IE,IL,IN,IS,IT,JM,JO,JP,KE,KH,KR,KW,KZ,LB,LI,LK,LT,LU,LV,MA,MD,MG,MK,ML,MO,MQ,MS,MT,MU,MX,MY,NG,NI,NL,NO,NP,NZ,OM,PA,PE,PF,PG,PH,PK,PL,PR,PS,PT,PW,PY,QA,RO,RS,RU,SA,SB,SE,SG,SI,SK,SN,ST,SV,TG,TH,TN,TO,TR,TT,TW,TZ,UA,UG,UK,US,UY,UZ,VA,VE,VU,XK,YE,ZA,VN 2019-05-04 17:50:14 /default/main/bio-rad/WORKAREA/default/templatedata/internet/product_SKU/data/LSR/Bio-Plex-Suspension-Array-Syst/Bio-Plex-Instruments/300-34376_0921120736052.xml templatedata/internet/product_SKU/data/LSR/Bio-Plex-Suspension-Array-Syst/Bio-Plex-Instruments/300-34376_0921120736052.xml 30034376-bio-plex-pro-wash-station 30034376 Bio-Plex Pro Wash Station Bio-Plex Pro™ Wash Station Microplate wash station for magnetic bead–based assays, includes magnetic plate carrier, waste bottle, 2 buffer bottles Microplate wash station for magnetic bead based assays, includes magnetic plate carrier, waste bottle, 2 liquid bottles Microplate wash station for magnetic bead– based assays, includes magnetic plate carrier, waste bottle, 2 buffer bottles /webroot/web/images/lsr/products/bioplex_suspension_array/sku_thumb/global/300-34376_tn.jpg /webroot/web/images/lsr/products/bioplex_suspension_array/sku_view/global/300-34376_view.jpg /webroot/web/images/lsr/products/bioplex_suspension_array/sku_feature/global/300-34376_feature.jpg ,VN RepEx 300-34376 Microplate wash station for magnetic bead– based assays, includes magnetic plate carrier, waste bottle, 2 liquid bottles 30034376, bio-plex, pro, wash, station, microplate, washing, magnetic-based, assays, plate, carrier 09/21/09 12:07 PM 12/31/37 11:59 PM AE,AI,AL,AM,AR,AT,AU,AZ,BA,BD,BE,BF,BG,BH,BN,BO,BR,BW,CA,CH,CL,CM,CN,CO,CR,CY,CZ,DE,DK,DO,DZ,EC,EE,EG,EH,ER,ES,ET,FI,FM,FO,FR,GA,GE,GF,GH,GP,GR,GT,GU,HK,HN,HR,HT,HU,ID,IE,IL,IN,IS,IT,JM,JO,JP,KE,KH,KR,KW,KZ,LB,LI,LK,LT,LU,LV,MA,MD,MG,MK,ML,MO,MQ,MS,MT,MU,MX,MY,NG,NI,NL,NO,NP,NZ,OM,PA,PE,PF,PG,PH,PK,PL,PR,PS,PT,PW,PY,QA,RO,RS,RU,SA,SB,SE,SG,SI,SK,SN,ST,SV,TG,TH,TN,TO,TR,TT,TW,TZ,UA,UG,UK,US,UY,UZ,VA,VE,VU,XK,YE,ZA,VN en LSR /LSR/Bio-Plex-Suspension-Array-Syst/Bio-Plex-Instruments N 0 false null false $ null true false true true false USD true true true /prd/en/US/adirect/biorad?cmd=ajaxAddToCart&AddToCartProductID=30034376&quantity= false false /prd/en/US/adirect/biorad?cmd=ajaxAddToCart&AddToCartProductID=30034376&CartQuote=QT&quantity= 1492 false true false /prd/en/US/adirect/biorad?cmd=ajaxAddToCart&AddToCartProductID=30034376&AddToDefaultWishList=true&quantity= 41115800 null Product detail page 30034376
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Number Description Options
6458 Bio-Plex Success Guide/Assay Sample Prep, Rev B Click to download
10028258 Instruction Manual, Bio-Plex Pro RBM Kidney Toxicity Assays, Rev A Click to download
10028259 Instruction Manual, Bio-Plex Pro RBM Kidney Toxicity Assays Quick Guide, Rev B Click to download
6347 Bio-Plex Pro RBM Assays Product Information Sheet, Rev A Click to download
6400 Profiling of Human, Canine, and Rat Urine Samples Using Bio-Plex Pro RBM Kidney Toxicity Assay, Rev A Click to download

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