Bio-Plex Pro™ RBM Rat Kidney Toxicity Assays

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Overview

Magnetic bead–based assays for the detection and measurement of rat kidney toxicity biomarkers. Available as premixed all-in-one kits.

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Description

Description

The Bio-Plex Pro RBM kidney toxicity assays, developed in partnership with Myriad RBM, comprise a highly relevant set of biomarkers for early detection and characterization of kidney toxicity/injury. Myriad RBM’s close collaboration with the Predictive Safety Testing Consortium (PSTC), FDA, and European Medicines Evaluation Agency (EMEA) was instrumental in the selection of markers found in these panels.

The assays are built on magnetic beads to enable robust quantification of multiple proteins in rat urine samples, providing valuable information throughout drug development — from lead optimization to preclinical and clinical protocol decision making. Assays are offered as premixed all-in-one kits for research involving:

  • Drug-induced kidney toxicity
  • Diabetes
  • High blood pressure
  • Glomerulonephritis
  • Polycystic kidney disease
  • Chronic infection
  • SLE (lupus) and other autoimmune disorders

Bio-Plex Pro RBM rat kidney toxicity assays are available as two panels and an albumin kit:

Panel 1
  • Clusterin
  • IL-18
  • KIM-1
  • MCP-1
  • Osteopontin
Panel 2
  • B2M
  • Calbindin
  • Cystatin C
  • NGAL
Albumin Kit
  • Albumin

Based on 6.5 µm magnetic beads, these assay panels are compatible with both vacuum and magnetic wash stations. Magnetic washing simplifies plate processing, provides increased throughput, and results in decreased variability and increased reproducibility.

Key Features

  • Optimized for high precision and lot-to-lot reproducibility of sample measurements
  • Magnetic beads for simplified plate processing
  • 2-level quality controls with lot-specific ranges
  • Assay quick guide to get you started right away
  • High-quality design ensures robust and reproducible measurement of nephrotoxicity biomarkers in human, rat, and canine urine samples

Ordering Options

Premixed all-in-one kits

Instrument Compatibility

More Information

See how Bio-Plex instruments and assays benefit researchers studying heart disease, leukemia, melanoma, and other cancers.

Ordering

Ordering

items

Use the filters below to refine results!

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171KTR1CK
1 x 96-well, includes magnetic capture beads, detection antibodies, standards, controls, diluent, buffers, streptavidin-PE, flat bottom plate, and plate seals, for the detection of 5 kidney toxicity markers in rat urine
bio-plex-pro-rbm-rat-toxicity-panel-2-171-ktr2ck-tn.jpg
171KTR2CK
1 x 96-well, includes magnetic capture beads, detection antibodies, standards, controls, diluent, buffers, streptavidin-PE, flat bottom plate, and plate seals, for the detection of 4 kidney toxicity markers in rat urine
bio-plex-pro-rbm-rat-toxicity-albumin-kit-171-ktr3ck-tn.jpg
171KTR3CK
1 x 96-well, includes magnetic capture beads, detection antibodies, standards, controls, diluent, buffers, streptavidin-PE, flat bottom plate, and plate seals, for the detection of albumin in rat urine

Accessories

Accessories

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171020100
Includes magnetic washer and adjustment hex tools for use in manual wash steps for all Bio-Plex Magnetic Assays
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171025001
Pkg of 40, 96-well plate, for use with Bio-Plex Pro wash stations when using magnetic bead–based assays
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30034376
Microplate wash station for magnetic bead–based assays, includes magnetic plate carrier, waste bottle, 2 buffer bottles

Documents

Documents

Number Description Options
6458
Bio-Plex Success Guide/Assay Sample Prep, Rev B
6335
Bio-Plex Multiplex Immunoassays Analyte Guide
10028258
Instruction Manual, Bio-Plex Pro RBM Kidney Toxicity Assays, Rev A
10028259
Instruction Manual, Bio-Plex Pro RBM Kidney Toxicity Assays Quick Guide, Rev B
6347
Bio-Plex Pro RBM Assays Product Information Sheet, Rev A
6400
Profiling of Human, Canine, and Rat Urine Samples Using Bio-Plex Pro RBM Kidney Toxicity Assay, Rev A