Gene:  WISP1, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain von Willebrand factor type C module thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq Mar 2011]

PrimePCR™ SYBR® Green Assay: WISP1, Human
WNT1 inducible signaling pathway protein 1

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0036389
Info:   Same primer pair as used in probe assay qHsaCEP0039113
List Price:    $146.00
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PrimePCR™ Probe Assay: WISP1, Human
WNT1 inducible signaling pathway protein 1

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0039113
List Price:    $214.00
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