Gene:  VHL, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B elongin C and cullin-2 and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF) which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: VHL, Human
von Hippel-Lindau tumor suppressor

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0036545
Info:   Same primer pair as used in probe assay qHsaCEP0039269
List Price:    $142.00
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PrimePCR™ Probe Assay: VHL, Human
von Hippel-Lindau tumor suppressor

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0039269
List Price:    $208.00
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