Gene:  TP53, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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This gene encodes tumor protein p53 which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest apoptosis senescence DNA repair or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation DNA-binding and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms which can regulate p53 transcriptional activity. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: TP53, Human
tumor protein p53

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0045022
Info:   Same primer pair as used in probe assay qHsaCEP0052284
List Price:    $142.00
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PrimePCR™ SYBR® Green Assay: TP53, Human
tumor protein p53

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0013658
Info:   Recommended - best coverage
List Price:    $142.00
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PrimePCR™ lncRNA SYBR® Green Assay:TP53, Human
tumor protein p53

Assay Type: SYBR® Green
Assay Design: exonic
Application: lncRNA Expression
Unique Assay ID: qhsaLED0104500
Info:   Same primer pair as used in probe assay qhsaLEP0181740
List Price:    $138.00
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PrimePCR™ Probe Assay: TP53, Human
tumor protein p53

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0052284
List Price:    $208.00
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PrimePCR™ lncRNA® Probe Assay:TP53, Human
tumor protein p53

Assay Type: Probe
Assay Design: exonic
Application: lncRNA Expression
Unique Assay ID: qhsaLEP0181740
Info:   Same primer pair as used in SYBR assay qhsaLED0104500
List Price:    $202.00
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