Gene:  SPAG1, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility as well as identification of proteins for targeted contraception are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: SPAG1, Human
sperm associated antigen 1

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0043012
Info:   Same primer pair as used in probe assay qHsaCEP0050274
List Price:    $142.00
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PrimePCR™ SYBR® Green Assay: SPAG1, Human
sperm associated antigen 1

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0007503
List Price:    $142.00
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PrimePCR™ Probe Assay: SPAG1, Human
sperm associated antigen 1

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0050274
List Price:    $208.00
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