Gene:  SMAD4, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer juvenile polyposis syndrome and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq Oct 2009]

PrimePCR™ SYBR® Green Assay: SMAD4, Human
SMAD family member 4

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0015670
Info:   Same primer pair as used in probe assay qHsaCIP0030084
List Price:    $142.00
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PrimePCR™ Probe Assay: SMAD4, Human
SMAD family member 4

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0030084
List Price:    $208.00
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