Gene:  RAD17, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17 a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC) and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene which encode four distinct proteins have been reported. Two pseudogenes located on chromosomes 7 and 13 have been identified. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: RAD17, Human
RAD17 homolog (S. pombe)

Assay Type: SYBR® Green
Assay Design: Exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0005133
List Price:    $142.00
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PrimePCR™ SYBR® Green Assay: RAD17, Human
RAD17 homolog (S. pombe)

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0045586
Info:   Recommended - best coverage; Same primer pair as used in probe assay qHsaCEP0052847
List Price:    $142.00
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PrimePCR™ Probe Assay: RAD17, Human
RAD17 homolog (S. pombe)

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0052847
List Price:    $208.00
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