Gene:  PTTG1, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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The encoded protein is a homolog of yeast securin proteins which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs which are required for its transforming and tumorigenic activities as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein although it partially localizes in the nucleus. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: PTTG1, Human
pituitary tumor-transforming 1

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0038120
Info:   Same primer pair as used in probe assay qHsaCIP0040843
List Price:    $142.00
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PrimePCR™ Probe Assay: PTTG1, Human
pituitary tumor-transforming 1

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0040843
List Price:    $208.00
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