Gene:  PSEN2, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase an enzyme that cleaves APP. Also it is thought that the presenilins are involved in the cleavage of the Notch receptor such that they either directly regulate gamma-secretase activity or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: PSEN2, Human
presenilin 2 (Alzheimer disease 4)

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0009358
Info:   Same primer pair as used in probe assay qHsaCIP0027160
List Price:    $142.00
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PrimePCR™ Probe Assay: PSEN2, Human
presenilin 2 (Alzheimer disease 4)

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0027160
List Price:    $208.00
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