Gene:  LIMK1, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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There are approximately 40 known eukaryotic LIM proteins so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq Feb 2011]

PrimePCR™ SYBR® Green Assay: LIMK1, Human
LIM domain kinase 1

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0011840
Info:   Same primer pair as used in probe assay qHsaCIP0028201
List Price:    $142.00
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PrimePCR™ Probe Assay: LIMK1, Human
LIM domain kinase 1

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0028201
List Price:    $208.00
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