Gene:  LATS1, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity indicating a role as a negative regulator of CDC2/cyclin A. In addition the C-terminal kinase domain binds to its own N-terminal region suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: LATS1, Human
LATS, large tumor suppressor, homolog 1 (Drosophila)

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0036525
Info:   Same primer pair as used in probe assay qHsaCIP0039249
List Price:    $142.00
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PrimePCR™ Probe Assay: LATS1, Human
LATS, large tumor suppressor, homolog 1 (Drosophila)

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0039249
List Price:    $208.00
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