Gene:  GAD1, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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This gene encodes one of several forms of glutamic acid decarboxylase identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: GAD1, Human
glutamate decarboxylase 1 (brain, 67kDa)

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0038024
Info:   Same primer pair as used in probe assay qHsaCIP0040747
List Price:    $142.00
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PrimePCR™ Probe Assay: GAD1, Human
glutamate decarboxylase 1 (brain, 67kDa)

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0040747
List Price:    $208.00
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