Gene:  Fxyd2, Mouse

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This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2 also known as the gamma subunit of the NaK-ATPase regulates the properties of that enzyme. FXYD1 (phospholemman) FXYD2 (gamma) FXYD3 (MAT-8) FXYD4 (CHIF) and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2) with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The Type III integral membrane protein encoded by this gene is the gamma subunit of the NaK-ATPase present on the plasma membrane. Although the NaK-ATPase does not depend on the gamma subunit to be functional it is thought that the gamma subunit modulates the enzyme's activity by inducing ion channel activity. Multiple transcript variants have been described for this gene that are expressed in tissue-specific and developmental stage-specific patterns and encode proteins that differ at the N-terminus. [provided by RefSeq Sep 2009]

PrimePCR™ SYBR® Green Assay: Fxyd2, Mouse
FXYD domain-containing ion transport regulator 2

Assay Type: SYBR® Green
Assay Design: Exonic
Application: Gene Expression
Unique Assay ID: qMmuCED0004551
List Price:    $142.00
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PrimePCR™ SYBR® Green Assay: Fxyd2, Mouse
FXYD domain-containing ion transport regulator 2

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qMmuCED0051075
Info:   Same primer pair as used in probe assay qMmuCEP0059501
List Price:    $142.00
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PrimePCR™ Probe Assay: Fxyd2, Mouse
FXYD domain-containing ion transport regulator 2

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qMmuCEP0059501
List Price:    $208.00
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