Gene:  FLT3, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains one transmembrane region and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis proliferation and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: FLT3, Human
fms-related tyrosine kinase 3

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0043927
Info:   Same primer pair as used in probe assay qHsaCEP0051189
List Price:    $142.00
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PrimePCR™ SYBR® Green Assay: FLT3, Human
fms-related tyrosine kinase 3

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0021972
Info:   Recommended - best efficiency
List Price:    $142.00
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PrimePCR™ Probe Assay: FLT3, Human
fms-related tyrosine kinase 3

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0051189
List Price:    $208.00
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