Gene:  ERBB3, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate bladder and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterized. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: ERBB3, Human
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0018397
Info:   Same primer pair as used in probe assay qHsaCIP0031829
List Price:    $142.00
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PrimePCR™ Probe Assay: ERBB3, Human
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0031829
List Price:    $208.00
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