Gene:  CR1, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes leukocytes glomerular podocytes and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas mesangiocapillary glomerulonephritis systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting conferring protection against severe malaria. Alternate allele-specific splice variants encoding different isoforms have been characterized. Additional allele specific isoforms including a secreted form have been described but have not been fully characterized. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: CR1, Human
complement component (3b/4b) receptor 1 (Knops blood group)

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0048412
Info:   Recommended - best coverage; Same primer pair as used in probe assay qHsaCEP0055672
List Price:    $142.00
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PrimePCR™ SYBR® Green Assay: CR1, Human
complement component (3b/4b) receptor 1 (Knops blood group)

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0013379
List Price:    $142.00
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PrimePCR™ Probe Assay: CR1, Human
complement component (3b/4b) receptor 1 (Knops blood group)

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0055672
List Price:    $208.00
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