Gene:  CBFA2T2, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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In acute myeloid leukemia especially in the M2 subtype the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene but the full-length natures of only three have been described. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: CBFA2T2, Human
core-binding factor, runt domain, alpha subunit 2; translocated to, 2

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0042423
Info:   Recommended - best coverage; Same primer pair as used in probe assay qHsaCEP0049685
List Price:    $146.00
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PrimePCR™ SYBR® Green Assay: CBFA2T2, Human
core-binding factor, runt domain, alpha subunit 2; translocated to, 2

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0009150
List Price:    $146.00
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PrimePCR™ Probe Assay: CBFA2T2, Human
core-binding factor, runt domain, alpha subunit 2; translocated to, 2

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0049685
List Price:    $214.00
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