Gene:  C4A, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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This gene encodes the acidic form of complement factor 4 part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha beta and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist such that individuals may have 1 2 or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Nov 2011]

PrimePCR™ SYBR® Green Assay: C4A, Human
complement component 4A (Rodgers blood group)

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0037519
Info:   Same primer pair as used in probe assay qHsaCEP0040242
List Price:    $146.00
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PrimePCR™ Probe Assay: C4A, Human
complement component 4A (Rodgers blood group)

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0040242
List Price:    $214.00
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