Gene:  BRCA2, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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Design and Validation of Real-Time PCR Primers-test
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Inherited mutations in BRCA1 and this gene BRCA2 confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq Dec 2008]

PrimePCR™ SYBR® Green Assay: BRCA2, Human
breast cancer 2, early onset

Assay Type: SYBR® Green
Assay Design: Exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0023857
List Price:    $142.00
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PrimePCR™ SYBR® Green Assay: BRCA2, Human
breast cancer 2, early onset

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0044922
Info:   Recommended - best coverage; Same primer pair as used in probe assay qHsaCEP0052184
List Price:    $142.00
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PrimePCR™ Probe Assay: BRCA2, Human
breast cancer 2, early onset

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0052184
List Price:    $208.00
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