Gene:  ALOXE3, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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This gene is a member of the lipoxygenase family which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R12R-epoxyeicosa-5Z9E14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha) which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq Sep 2009]

PrimePCR™ SYBR® Green Assay: ALOXE3, Human
arachidonate lipoxygenase 3

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0017551
Info:   Same primer pair as used in probe assay qHsaCIP0031320
List Price:    $142.00
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PrimePCR™ Probe Assay: ALOXE3, Human
arachidonate lipoxygenase 3

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0031320
List Price:    $208.00
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