Gene:  AIFM1, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. [provided by RefSeq May 2010]

PrimePCR™ SYBR® Green Assay: AIFM1, Human
apoptosis-inducing factor, mitochondrion-associated, 1

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0022006
Info:   Same primer pair as used in probe assay qHsaCIP0033258
List Price:    $142.00
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PrimePCR™ Probe Assay: AIFM1, Human
apoptosis-inducing factor, mitochondrion-associated, 1

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0033258
List Price:    $208.00
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