Gene:  ACTN4, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions where it is involved in binding actin to the membrane. In contrast skeletal cardiac and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle alpha actinin isoform which is concentrated in the cytoplasm and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: ACTN4, Human
actinin, alpha 4

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0012278
Info:   Same primer pair as used in probe assay qHsaCIP0028372
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PrimePCR™ Probe Assay: ACTN4, Human
actinin, alpha 4

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0028372
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