This is the amplicon context sequence in accordance with the minimum information for the publication of real-time quantitative PCR experiements (MIQE) guidelines. For more details, please refer to the following publication, "Primer Sequence Disclosure: A Clarification of the MIQE Guidelines."
Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.
Info: Same primer pair as used in SYBR assay qhsaLED0103816
PrimePCR™ IncRNA PreAmp for Probe Assay: IL12RB2, Human
PrimePCR™ IncRNA Template for Probe Assay: IL12RB2, Human
The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases such as Crohn's disease and leprosy which is thought to contribute to the inflammatory response and host defense. [provided by RefSeq Jul 2008]