PrimePCR™ Probe Assay: OAZ1, Dog


Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

List Price:    $208.00
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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qCfaCEP0016100
Assay Design:   Exonic
Chromosome Location:   20:56769499-56769622question
Amplicon Length:   94
Splice Variants Targeted:   ENSCAFT00000046742

Gene Information

The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as by inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs, and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization (PMID:16120325). [provided by RefSeq, Jul 2014]

Gene Symbol:   OAZ1
Gene Name:   Ornithine decarboxylase antizyme 1
Aliases:   Not Available
RefSeq:   NM_001127234
Ensembl:   ENSCAFG00000019411
Entrez:   476749
UniGene:   Cfa.39486
Chromosome Mapping:   20

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